Antiobesity and Antioxidant Potentials of Selected Palestinian Medicinal Plants

Jamous R.M., Abuzaitoun S.Y, Akkawi R.J, Ali-Shtayeh M.S.
Journal Name
Evidence-based Complementary and Alternative Medicine

We evaluated the antioxidant and porcine pancreatic lipase inhibition (PPLI) activities of 90 plants extract. The antioxidant activity was measured using the free-radical scavenging capacity (DPPH), and reducing power (RP) assays. The pancreatic lipase inhibition assay was used to determine the PPLI activity of plant extracts. Among the 90 plant extracts examined, 41.0 % crude extracts showed anti-lipase activity of more than 50%. The most active plants by means of IC50 value were: Camellia sinensis (0. 5 mg/ml), Ceratonia siliqua (leaves) (0.8 mg/mL), Curcuma longa (0.8 mg/mL), Sarcopoterium spinosum (1.2 mg/mL), and Mentha spicata (1.2 mg/mL). The antioxidant activity of plant extracts using the DPPH and RP assays reveals comparable results. The most active antioxidant extracts using both assays were the leaves and fruit epicarp of Rhus coriaria, areal parts of Sarcopoterium spinosum, and leaves of Ceratonia siliqua. Our results suggest natural resources that possess strong antioxidant and pancreatic lipase inhibitory activities with potential applications in the treatment and prevention of obesity and overweight. The extracts of Camellia sinensis, Ceratonia siliqua, Curcuma longa, Sarcopoterium spinosum, and Mentha spicata were proved to have a great potential as antioxidants and anti-obesity agents. Keywords: Antiobesity, orlistat, weight-reducing effects, pancreatic lipase inhibition