Synthesis and characterization of some antifungal active hydrazones from combined of several functionalized hydrazides with with Di-2-pyridyl ketone

Authors
Al-Nuri, M., Haroun, A., Warad, I., Mahfouz, R. M., Al-Resayes, S., and Ali-Shtayeh, M. S.
Journal Name
Journal of Saudi Chemical Society
Volume
2
Issue
1
Pages From
313
To
318
Date
Abstract

Trichophyton mentagrophytes, Microsporum canis and Trichophyton rubrum. Pyridlhydrazone derivatives [1-5] were synthesized for the first time by condensation of di-2-pyridyl ketone with different hydrazides individually. The corresponding solid phase hydrazide-hydrazones were collected from acidic-ethanolic medium after 8-10 hours of reflux in very good to excellent yields and purified twice by ethanol/water re-crystallization process. All the synthesized compounds are characterized by IR, 1 H and 13 C NMR, FAB-MS and other physical analyses tests. The microbiological antifungal activity was carried out toward Trichophyton mentagrophytes, Microsporum canis and Trichophyton rubrum.